The field of neurology can appear intimidating and hard to understand. The Top 50 Essential Elements in Neurology provides a quick review of the most salient and critically important elements related to key clinical skills, highly relevant clinical topics, neuroimaging, and sections dedicated to discovery and our own neuroanatomical design. The purpose of this application is to highlight the most meaningful teaching points related to our field that are geared towards students, residents, fellows, advanced practice providers, and physicians. What is truly exciting is that the information contained within the application may be immediately applied within the clinical setting. The contents aim to improve one’s knowledge base in neurology by demystifying complex topics while aiming to inspire future innovative efforts related to clinical research and the care of patients afflicted with neurological disease.