Jonathan Harker, a newly qualified English solicitor, visits Count Dracula at his castle in the Carpathian Mountains to help the Count purchase a house near London. Ignoring the Count's warning, Harker wanders the castle and encounters three vampire women; Dracula rescues Harker, and gives the women a small child bound inside a bag. Harker awakens in bed; soon after, Dracula leaves the castle, abandoning him to the women; Harker escapes with his life and ends up delirious in a Budapest hospital. Dracula takes a ship for England with boxes of earth from his castle. The captain's log narrates the crew's disappearance until he alone remains, bound to the helm to maintain course. An animal resembling a large dog is seen leaping ashore when the ship runs aground at Whitby.

Lucy Westenra's letter to her best friend, Harker's fiancée Mina Murray, describes her marriage proposals from Dr. John Seward, Quincey Morris, and Arthur Holmwood. Lucy accepts Holmwood's, but all remain friends. Mina joins her friend Lucy on holiday in Whitby. Lucy begins sleepwalking. After his ship lands there, Dracula stalks Lucy. Mina receives a letter about her missing fiancé's illness, and goes to Budapest to nurse him. Lucy becomes very ill. Seward's old teacher, Professor Abraham Van Helsing, determines the nature of Lucy's condition, but refuses to disclose it. He diagnoses her with acute blood-loss. Van Helsing places garlic flowers around her room and makes her a necklace of them. Lucy's mother removes the garlic flowers, not knowing they repel vampires. While Seward and Van Helsing are absent, Lucy and her mother are terrified by a wolf and Mrs. Westenra dies of a heart attack; Lucy dies shortly thereafter. After her burial, newspapers report children being stalked in the night by a beautiful lady, and Van Helsing deduces it is Lucy. The four go to her tomb and see that she is a vampire. They stake her heart, behead her, and fill her mouth with garlic. Jonathan Harker and his now-wife Mina have returned, and they join the campaign against Dracula.