John Wesley’s Explanatory Notes explains difficult to understand words and phrases, providing insight into nearly every verse in the Bible.

John Wesley's explanatory notes on the Old Testament were written several years after his notes on the New Testament, and are based on the earlier works of Matthew Henry's 'Exposition of the Old and New Testaments', and Matthew Poole's 'English Annotations on the Holy Bible'. Extracts from both of these works are paraphrased and abridged by Wesley for the Explanatory Notes on the Old Testament, unlike the Explanatory Notes on the New Testament, which were entirely of his own composition.

The Notes Upon The New Testament is considered to be one of John Wesley's principal works, and its readability, influence and popularity has remained since the time of its publication until today.